The effect of human fibrinolysin on pulmonary metastases of Walker 256 carcinosarcoma.

Abstract

Summary 1.A significant in vitro fibrinolytic activity could be obtained in plasma of rats given human fibrinolysin intravenously. 2.Pulmonary metastases were produced in a large percentage (81 per cent) of control rats given inoculations intravenously of 100,000 Walker 256 carcinosarcoma cells/ml. When cells were inoculated into animals with marked fibrinolytic activity produced by human fibrinolysin, the takes of tumor as measured by pulmonary metastases were markedly reduced to 25 per cent.