Concepedia

Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury

Andrew P. Halestrap, CP Connern, Elinor J. Griffiths, Paul M. Kerr

1997 · 420 citations · 17 references

DOI

Concepts

References

17

The Ca2+-induced membrane transition in mitochondria

Douglas R. Hunter, Robert A. Haworth · Archives of Biochemistry and Biophysics · 1979 · 850 citations

, , +12

Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress.

M Crompton, H Ellinger, A Costi · PubMed · 1988 · 848 citations · Full text

, , +17

Inhibition of Ca2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl <i>cis-trans</i> isomerase and preventing it interacting with the adenine nucleotide translocase

Andrew P. Halestrap, A M Davidson · Biochemical Journal · 1990 · 746 citations · Full text

, , +17

Protection by Cyclosporin A of Ischemia/Reperfusion-Induced Damage in Isolated Rat Hearts

Elinor J. Griffiths, Andrew P. Halestrap · Journal of Molecular and Cellular Cardiology · 1993 · 574 citations

, , +14

Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to <i>t</i>-butylhydroperoxide

A. L. Nieminen, Alice K. Saylor, Samuel A. Tesfai et al. · Biochemical Journal · 1995 · 381 citations · Full text

, , +17