Identification of<i>INS</i>and<i>KCNJ11</i>gene mutations in type 1B diabetes in Japanese children with onset of diabetes before 5 yr of age

Abstract

Our results suggest that monogenic forms of diabetes, particularly INS gene mutations, can be detected in Japanese patients classified with type 1B. Mutation screening, at least of the INS gene, is recommended for Japanese patients diagnosed as autoantibody negative at <5 yr of age.