Concepedia

Acetyl-L-Carnitine prevents and reverts experimental chronic neurotoxicity induced by oxaliplatin, without altering its antitumor properties.

Orlando Ghirardi, Pietro Giudice, Claudio Pisano, Mario Vertechy, Augusta Bellucci, Loredana Vesci, Sante Cundari, Mariarosaria Miloso, Laura Rigamonti, Gabriella Nicolini,

PubMed · 2005 · 76 citations · 24 references

Abstract

ALC is effective in the prevention and treatment of chronic OHP-induced peripheral neurotoxicity in an experimental rat model.

References

24

New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening

Philip Skehan, Ritsa Storeng, Dominic A. Scudiero et al. · JNCI Journal of the National Cancer Institute · 1990 · 9.7K citations

Phase III Multicenter Randomized Trial of Oxaliplatin Added to Chronomodulated Fluorouracil–Leucovorin as First-Line Treatment of Metastatic Colorectal Cancer

Sylvie Giacchetti, B Perpoint, Rachid Zidani et al. · Journal of Clinical Oncology · 2000 · 1.4K citations

Carnitine and Its Role in Fatty Acid Metabolism* *Work reviewed from this laboratory was supported by grants A-1465 and A-1682 from the National Institutes of Health.

Irving B. Fritz · Advances in lipid research · 1963 · 445 citations

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Two consecutive phase II studies of oxaliplatin (L-OHP) for treatment of patients with advanced colorectal carcinoma who were resistant to previous treatment with fluoropyrimidines

D. Machover, Eduardo Díaz‐Rubio, Aimery de Gramont et al. · Annals of Oncology · 1996 · 433 citations · Full text

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Effects of different schedules of oxaliplatin treatment on the peripheral nervous system of the rat

Guido Cavaletti, G Tredici, M G Petruccioli et al. · European Journal of Cancer · 2001 · 286 citations

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