<i>CYP2E1</i>,<i>GSTM1</i>and<i>GSTT1</i>genetic polymorphisms and susceptibility to antituberculosis drug-induced hepatotoxicity: a nested case-control study

Abstract

This is the first study of the involvement of CYP2E1, GSTM1 and GSTT1 genetic polymorphisms in ATDH using a nested case-control population-based prospective cohort design. We could not confirm positive associations of genetic polymorphisms of CYP2E1 RsaI, CYP2E1 DraI, GSTM1 null and GSTT1 null with ATDH reported by various groups, in our Chinese TB population.