IGFBP-4 Anti-Angiogenic and Anti-Tumorigenic Effects Are Associated with Anti-Cathepsin B Activity

High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells

Yves Durocher · Nucleic Acids Research · 2002 · 1K citations · Full text

Viral Replication, Immunology, Transient Transfection +18

Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis

Johanna A. Joyce, Amos Baruch, Kareem A. H. Chehade et al. · Cancer Cell · 2004 · 627 citations · Full text

Multistage Tumorigenesis, Angiogenesis, Cathepsin Cysteine Proteases +11

Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence.

John I. Jones, A Gockerman, W H Busby et al. · Proceedings of the National Academy of Sciences · 1993 · 513 citations · Full text

Developmental Biology, Signal Transduction, Molecular Physiology +15

Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumour tissues

Michael Buck, D G Karustis, Nancy A. Day et al. · Biochemical Journal · 1992 · 421 citations · Full text

Glycobiology, Pathology, Cell Proliferation +23

Further studies on the activation of procollagenase, the latent precursor of bone collagenase. Effects of lysosomal cathepsin B, plasmin and kallikrein, and spontaneous activation

Yves Eeckhout, Gilbert Vaes · Biochemical Journal · 1977 · 389 citations · Full text

Spontaneous Activation, Cellular Physiology, Osteoporosis +19