Organic & Biomolecular Chemistry · 2015 · 16 citations · 12 references
Life SciencesGeneticsMolecular BiologyGenetic EngineeringMicrobial GeneticsPost-translational ModificationAmino Acid MetabolismGenetic CodeGenetic Engineering Of MicroorganismsProtein SynthesisSynthetic Genetic CodeUniversal Genetic Code
We report the synthesis and genetic encoding of a recently discovered post-translational modification, 2-hydroxyisobutyryl-lysine, to the genetic code of E. coli. The production of homogeneous proteins containing this amino acid will facilitate the study of modification in full-length proteins.
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SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways
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