Human Polycystin-2 Transgene Dose-Dependently Rescues ADPKD Phenotypes in Pkd2 Mutant Mice

Two Populations of Node Monocilia Initiate Left-Right Asymmetry in the Mouse

James McGrath, Stefan Somlo, Svetlana Makova et al. · Cell · 2003 · 804 citations · Full text

Life Sciences, Biology, Developmental Biology +10

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

Jonathan M. Shillingford, Noel Murcia, Claire H. Larson et al. · Proceedings of the National Academy of Sciences · 2006 · 798 citations · Full text

Medicine, Molecular Genetics, Nephrology +15

The Molecular Basis of Focal Cyst Formation in Human Autosomal Dominant Polycystic Kidney Disease Type I

Feng Qian, Terry Watnick, Luiz F. Onuchic et al. · Cell · 1996 · 615 citations · Full text

Medicine, Genetics, Molecular Genetics +11

Independent regulatory elements in the nestin gene direct transgene expression to neural stem cells or muscle precursors

Lyle B. Zimmerman, Urban Lendahl, Miles G. Cunningham et al. · Neuron · 1994 · 587 citations

Life Sciences, Genetics, Neuroscience +17

Somatic Inactivation of Pkd2 Results in Polycystic Kidney Disease

Guanqing Wu, Vivette D. D’Agati, Yiqiang Cai et al. · Cell · 1998 · 572 citations · Full text

Medicine, Genetics, Molecular Genetics +15