Concepedia

Covalent binding of zomepirac glucuronide to proteins: evidence for a Schiff base mechanism.

Philip C. Smith, Leslie Z. Benet, Antony F. McDonagh

Drug Metabolism and Disposition · 1990 · 124 citations · 0 references

Concepts

PharmacyBiochemistryPharmacologyBiochemical PharmacologyPharmaceutical ToxicologyProtein BiochemistryDrug DispositionLigand BindingProtein Adduct FormationProtein BindingProtein StructureAcyl Glucuronide FormationCovalent Drug BindingCovalent Protein BindingCysteine Adduct FormationLysine Adduct FormationLysine ConjugationThiol ChemistryToxicological Evaluation