Advanced Synthesis & Catalysis · 2014 · 53 citations · 50 references
Natural SciencesChemistryCatalysisOrganic ChemistryCatalytic MechanismsHeterocycle SynthesisMigratory InsertionOrganic SynthesisAmination ReactionsFunctional Group ToleranceIndole ChemistryIndole SynthesisStereoselective AminationSubstrate ScopeSubstrate Scope ExpansionSubstrate Scope Profiling
Abstract A highly effective silver(I)‐mediated CH amination of 2‐alkenylanilines has been developed to afford a diverse range of substituted indoles. High functional group tolerance, broad substrate scope, simple/fast/high‐yielding reaction, and recovery/reuse of the inexpensive silver oxidant are noteworthy. Furthermore, an uncommon migratory process of β‐monosubstituted 2‐alkenylanilines with solvent‐dependence was demonstrated. magnified image
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Indole synthesis – something old, something new
Martyn Inman, Christopher J. Moody · Chemical Science · 2012 · 646 citations
Competition Methods and Scales for Alkyl Radical Reaction Kinetics
Martin Newcomb · Tetrahedron · 1993 · 617 citations