Concepedia

Neuregulin-1 improves right ventricular function and attenuates experimental pulmonary arterial hypertension

Pedro Mendes‐Ferreira, C. Maia-Rocha, Rui Adão, Maria José Mendes, Diana Santos‐Ribeiro, B.S. Alves, Rui Cerqueira, Paulo Castro‐Chaves, André P. Lourenço, Gilles W. De Keulenaer,

Cardiovascular Research · 2015 · 40 citations · 34 references

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Abstract

rhNRG-1 treatment attenuates pulmonary arterial and RV remodelling, and dysfunction in a rat model of MCT-induced PAH and has direct anti-remodelling effects on the pressure-overloaded RV.

References

34

Neuregulin1/ErbB4 Signaling Induces Cardiomyocyte Proliferation and Repair of Heart Injury

Kevin Bersell, Shima Arab, Bernhard Haring et al. · Cell · 2009 · 1K citations · Full text

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Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension.

Marc Humbert, Gianpaola Monti, F Brénot et al. · American Journal of Respiratory and Critical Care Medicine · 1995 · 777 citations

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Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension

S. A. van Wolferen, J. Tim Marcus, A. Boonstra et al. · European Heart Journal · 2007 · 747 citations

Chronic Pulmonary Artery Pressure Elevation Is Insufficient to Explain Right Heart Failure

Harm Jan Bogaard, Ramesh Natarajan, Scott C. Henderson et al. · Circulation · 2009 · 502 citations · Full text

A Phase II, Randomized, Double-Blind, Multicenter, Based on Standard Therapy, Placebo-Controlled Study of the Efficacy and Safety of Recombinant Human Neuregulin-1 in Patients With Chronic Heart Failure

Runlin Gao, Jian Zhang, Liuquan Cheng et al. · Journal of the American College of Cardiology · 2010 · 272 citations

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