The Schizophrenia-like Psychoses of Epilepsy

TLDR

Temporal‑lobe epilepsy can give rise to chronic paranoid psychoses that resemble schizophrenia, typically emerging as seizure frequency wanes and presenting with paranoid ideas, auditory hallucinations, and occasional thought disorder. The cases involved temporal‑lobe epilepsy with complex auras, occasional nocturnal seizures, and EEG foci detectable mainly during sleep‑sphenoidal recordings. Compared with schizophrenia, these psychoses showed religiously tinted paranoid content, preserved affect, and no progression to hebephrenia. The study was reported in 1957 by D.

Abstract

In 1953, in an article intended for the general practitioner, Denis Hill made a brief reference to the chronic paranoid psychoses which may develop in association with temporal lobe epilepsy. He described the condition as likely to come on when the seizures were diminishing in frequency, as appearing gradually with onset in middle age, and as resembling a paranoid schizophrenic state. In 1957, D. A. Pond, from the same department of applied electro-physiology at the Maudsley Hospital, gave a more detailed account of the clinical features. He described the psychotic states as closely resembling schizophrenia, with paranoid ideas which might become systematized, ideas of influence, auditory hallucinations often of a menacing quality; and occasional frank thought disorder with neologisms, condensed words and inconsequential sentences. There were, however, also some points of difference, of a quantitative rather than qualitative kind: a religious colouring of the paranoid ideas was common; the affect tended to remain warm and appropriate; and there was no typical deterioration to the hebephrenic state. All the patients had epilepsy arising from the temporal lobe region with complex auras; occasional major seizures occurred in sleep only. EEG foci, always present, were sometimes only to be demonstrated in sleep-sphenoidal records. The epilepsy began some years before the psychotic symptoms, usually in the late teens or the twenties; and the latter often seemed to begin as the epileptic attacks were diminishing in frequency, either spontaneously or with drug treatment.