Journal of Mechanics in Medicine and Biology · 2015 · 12 citations · 6 references
PharmacyPharmaceuticsPharmacokineticsDrug DeliveryFinite Element MethodsTransdermal Drug DeliveryDrug Delivery SystemsDrug DistributionDrug Distribution KineticsTransdermal FormulationsDrug Concentration CalculationsDrug Concentration PredictionDrug Diffusion KineticsDrug Diffusion ModelingSkin Permeation ModelingTissue Distribution SimulationTransdermal Delivery SystemsTransdermal Drug Delivery Systems
A mathematical model is proposed to study the amount of drug concentration at various regions of human dermal system. The model is based on the mechanism of transdermal drug delivery systems (TDDS) with appropriate boundary conditions. The analytical solution for such problems either does not exist or is too complicated to handle. In this paper, finite element and Crank–Nicholson methods were used to find the solution of the formulated model with greater accuracy.
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