Germline Mutations in <i>BRCA1 </i> and <i> BRCA2 </i> in Breast-Ovarian Families From a Breast Cancer Risk Evaluation Clinic

Abstract

These results suggest that at least half of breast/ovarian families evaluated in a high-risk cancer evaluation clinic may have germline mutations in BRCA1 or BRCA2. Whether the remaining families have mutations in noncoding regions in BRCA1, mutations in other, as-yet-unidentified, low-penetrance susceptibility genes, or represent chance clustering remains to be determined.