Chemical Communications · 2015 · 14 citations · 16 references
PharmacyBiophysicsPharmaceuticsDrug DeliveryNanoparticle Drug DeliveryStimuli-responsive Drug DeliveryMagnetic OxidesMagnetic-responsive Drug DeliveryNanomedicineNanoparticle Delivery SystemsNanoparticle FormulationsTheranostic NanoparticlesContrast Agent RelaxivityDrug-loaded MicellesIron Oxide NanoparticlesMagnetic Nanoparticle Drug CarriersMagnetic Nanoparticle Drug DeliveryMicellesNanoparticle-based Contrast AgentsSuperparamagnetic Contrast Agents
PLA2-responsive and superparamagnetic iron oxide (SPIO) nanoparticle-loaded phospholipid micelles were developed. The release of a phospholipid-conjugated dye from these micelles was triggered due to phospholipid degradation by phospholipase A2. The high relaxivity of the encapsulated SPIO could enable non-invasive magnetic resonance imaging.
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