Concepedia

Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

Barbara Varnum‐Finney, Lanwei Xu, Carolyn Brashem‐Stein, Cynthia Nourigat, David Flowers, Sonia Bakkour, Warren S. Pear, Irwin D. Bernstein

Nature Medicine · 2000 · 637 citations · 25 references

DOI

Concepts

References

25

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

Leif W. Ellisen, Daniel C. West, A. Lee Soreng et al. · Cell · 1991 · 1.7K citations

, , +14

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

Freddy Radtke, Anne E. Wilson, Gerlinde Stark et al. · Immunity · 1999 · 1.4K citations · Full text

, , +14

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

Stephen L. Nutt, Barry Heavey, Antonius Rolink et al. · Nature · 1999 · 1.2K citations

, , +14

Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

John C. Pui, David Allman, Lanwei Xu et al. · Immunity · 1999 · 935 citations · Full text

, , +17

Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow

Warren S. Pear, Juli P. Miller, Lanwei Xu et al. · Blood · 1998 · 738 citations

, , +12