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Studies on the transfer of lymph node cells. II. Effects of experimental manipulation of the donor system.
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1954
Year
ImmunologyGlucocorticoidExperimental ManipulationImmunotherapyCortisone-treated RecipientsLymphatic SystemGraft SurvivalCell TransplantationXenotransplantationTransplantationAutoimmunityLymph Node CellsBlood TransplantationEndocrinologyCell EngineeringCell BiologyDonor SystemTransplant ImmunologyDonor RabbitsImmunosuppressive TherapyControl DonorsVeterinary ScienceImmunosuppressionMedicineGraft Rejection
The effects of administration of cortisone were also studied in this system. Such treatment of donor rabbits resulted in lymph nodes which were smaller and yielded approximately one-sixth the number of cells of control donors, but the cells so derived were usually as effective, or, in some cases, slightly less so, than in the case of non-hormone treated controls. Popliteal lymph node cells derived from normal donors 4 days after their injection with dysentery organisms were as effective in cortisone-treated recipients as in control animals. However, when the cells were obtained 2 days after the injection of the donors with antigen, and transferred to cortisone treated recipients and to controls, the agglutinin titers of the former were in some instances lower than those of the non-hormone treated animals.