Human diabetic neovascular membranes contain high levels of urokinase and metalloproteinase enzymes.

Abstract

Human diabetic neovascular membranes contain high levels of urokinase and MMP. The increased activity of proteinases in the final common pathway of retinal neovascularization indicates that inhibition of these enzymes may be a useful therapeutic target as an alternative approach in the management of proliferative retinopathies.