Transforming growth factor-beta 1 knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease.

Establishment in culture of pluripotential cells from mouse embryos

Martin Evans, M. H. Kaufman · Nature · 1981 · 8.6K citations

Life Sciences, Cell Biology, Developmental Biology +14

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

Marcia M. Shull, Ilona Ormsby, Ann B. Kier et al. · Nature · 1992 · 3K citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +14

RAG-1-deficient mice have no mature B and T lymphocytes

Peter Mombaerts, John Iacomini, Randall S. Johnson et al. · Cell · 1992 · 2.9K citations

Life Sciences, Genetics, Immunology +13

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

Yoichi Shinkai · Cell · 1992 · 2.6K citations

Life Sciences, Genetics, Immunology +14

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

Philippe Soriano, Charles A. Montgomery, Robert S. Geske et al. · Cell · 1991 · 2K citations

Medicine, Molecular Biology, Oncology +12