Innovation in the pharmaceutical industry

A membrane lipid imbalance plays a role in the phenotypic expression of cystic fibrosis in <i>cftr</i> ^−/− mice

Steven D. Freedman, Mark H. Katz, Eliza M. Parker et al. · Proceedings of the National Academy of Sciences · 1999 · 285 citations · Full text

Life Sciences, Biochemistry, Pathobiology +17

How many leads from HTS?

Roger Lahana · Drug Discovery Today · 1999 · 150 citations

Pharmacy, Medicinal Chemistry, Lead Optimization +5

Folate deficiency and decreased brain 5-hydroxytryptamine synthesis in man and rat

M.I. Botez, Simon N. Young, Jocelyne Bachevalier et al. · Nature · 1979 · 115 citations

Life Sciences, Neurobiology, Neuroscience +9

Phospholipid Spectrum Disorder in Psychiatry

David Healy · Journal of the Royal Society of Medicine · 1999 · 108 citations · Full text

Medicine, Psychiatry, Neuropsychiatry +1

Characterization of the Influence of Unsaturated Free Fatty Acids on Brain GABA/Benzodiazepine Receptor Binding In Vitro

Michael‐Robin Witt, Mogens Brøndsted Nielsen · Journal of Neurochemistry · 1994 · 71 citations

Medicine, Neuroscience, Pharmacology +16