The selective dopamine<scp>D</scp>₃receptor antagonist<scp>SB</scp>‐277011‐<scp>A</scp>significantly decreases binge‐like consumption of ethanol in<scp>C</scp>57<scp>BL</scp>/<scp>J</scp>6 mice

Abstract

The authors show that the dopamine D3 antagonist SB-277011-A consistently and persistently decrease binge-like EtOH consumption at 30 mg/kg and it decreases binge-like consumption on days 3, 7, 9, and 11-13 at 15 mg/kg. These findings suggest that the brain's D3 receptor may also be involved in not only ethanol reward but binge drinking as well.