Demonstration of host resistance against isotransplantation of lymphomas induced by the Gross agent.

Abstract

Summary It was found that a state of relative resistance can be built up in highly inbred skin-compatible C3H mice against the isotransplantation of lymphomas recently induced in the same strain by the Gross virus. Resistance could be built up in two different ways: by pretreating the recipients with homografts of other Gross lymphomas, induced in genetically incompatible mice, or with sub-threshold doses of cells from the same isologous lymphoma. The resistance was relatively weak in comparison with the previously demonstrated antigenicity of methylcholanthrene-induced sarcomas and polyoma-induced tumors. There appears to be partial or complete cross-resistance between different lymphomas induced by the Gross virus.