Concepedia

Prothrombin deficiency caused by compound heterozygosity for two novel mutations in the prothrombin gene associated with a bleeding tendency

Hristo Stanchev, Malou Philips, Bruno O. Villoutreix, Lise Aksglæde, Stefan Lethagen, Sixtus Thorsen

Thrombosis and Haemostasis · 2006 · 18 citations · 17 references

DOI

Concepts

Abstract

Prothrombin deficiency causedbycompound heterozygosityfor twonovel mutationsin theprothrombin gene associatedwithableeding tendency -

References

17

The refined 1.9‐Å X‐ray crystal structure of d‐Phe‐Pro‐Arg chloromethylketone‐inhibited human <i>α</i>‐thrombin: Structure analysis, overall structure, electrostatic properties, detailed active‐site geometry, and structure‐function relationships

Wolfram Bode, Andrej Karshikov · Protein Science · 1992 · 626 citations · Full text

, , +17

Prothrombin deficiency results in embryonic and neonatal lethality in mice

William Sun, David P. Witte, Jay L. Degen et al. · Proceedings of the National Academy of Sciences · 1998 · 259 citations

, , +17

Molecular Dissection of Na+ Binding to Thrombin

Agustin O. Pineda, Christopher J. Carrell, Leslie A. Bush et al. · Journal of Biological Chemistry · 2004 · 180 citations · Full text

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Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice

Jiachun Xue, Qingyu Wu, Lisa A. Westfield et al. · Proceedings of the National Academy of Sciences · 1998 · 168 citations · Full text

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Incidence of retinopathy of prematurity from 1996 to 2000

Michael F. Chiang, Raymond R. Arons, John T. Flynn et al. · Ophthalmology · 2004 · 145 citations

, , +10