Articular Cartilage Endurance and Resistance to Osteoarthritic Changes Require Transcription Factor Erg

Abstract

The study shows for the first time that Erg is a critical molecular regulator of the endurance of articular cartilage during postnatal life and that Erg can mitigate spontaneous and experimental OA. Erg appears to do this through regulating expression of PTHrP and lubricin, factors known for their protective roles in joints.