Cyclopamine decreased the expression of Sonic Hedgehog and its downstream genes in colon cancer stem cells. - Concepedia

Concepedia

Publication | Closed Access

Cyclopamine decreased the expression of Sonic Hedgehog and its downstream genes in colon cancer stem cells.

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References

2014

Year

Bat-Erdene Batsaikhan, Kozo Yoshikawa, Nobuhiro Kurita, Takashi Iwata, Chie Takasu, Hideya Kashihara, Mitsuo Shimada

Abstract

Overall, these findings show that cyclopamine treatment could down-regulate the expression of stemness markers, shh downstream genes and EMT markers on HCT-116 spheres.