Concepedia

Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival.

Heinz-Josef Lenz, Cynthia G. Leichman, Kathleen D. Danenberg, P. V. Danenberg, Susan Groshen, Hartley Cohen, Loren Laine, Peter F. Crookes, Howard Silberman, Joaquina Baranda,

Journal of Clinical Oncology · 1996 · 348 citations · 21 references

DOI

Abstract

The genetic expression of TS (TSmRNA level) influences response to 5FU-based chemotherapy and survival for a cohort of patients with primary gastric cancer. Confirmation of these data could lead to therapeutic decisions based on specific molecular properties within a tumor.

References

21

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Analytical Biochemistry · 1987 · 63.2K citations

, , +7

Fluorinated Pyrimidines, A New Class of Tumour-Inhibitory Compounds

Charles Heidelberger, P Danneberg, Dorothy Mooren et al. · Nature · 1957 · 1.6K citations

, , +5

Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors.

P. G. Johnston, Heinz-Josef Lenz, Cynthia G. Leichman et al. · PubMed · 1995 · 678 citations

, , +16

Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate

Daniel V. Santi, Charles S. McHenry, Hans Sommer · Biochemistry · 1974 · 618 citations

, , +16

The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer.

Patrick G. Johnston, Edwin R. Fisher, Howard E. Rockette et al. · Journal of Clinical Oncology · 1994 · 409 citations