Concepedia

Annexin <scp>A1</scp> mimetic peptide controls the inflammatory and fibrotic effects of silica particles in mice

Patrícia Gonçalves Trentin, Tatiana Paula Teixeira Ferreira, Ana Arantes, Bianca Torres Ciambarella, R.S.B. Cordeiro, R.J. Flower, Mauro Perretti, Marco A. Martins, P M R Silva

British Journal of Pharmacology · 2015 · 58 citations · 35 references

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Abstract

Collectively, our findings reveal novel protective properties of the ANXA1 derived peptide Ac2-26 on the inflammatory and fibrotic responses induced by silica, and suggest that ANXA1 mimetic agents might be a promising strategy as innovative anti-fibrotic approaches for the treatment of silicosis.

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