PubMed · 2007 · 20 citations · 6 references
Life SciencesGeneticsImmunologyHematopathologyHuman GeneticsImmunogeneticsDonor MatchingHaplotype AnalysisHistocompatibilityHla MatchingHla TypingMajor Histocompatibility ComplexHla Allele Frequency DistributionHla Allele MatchingHla Allele PolymorphismHla AllelesHla ImmunogeneticsMhc HaplotypesMolecular Hla TypingPopulation Hla Frequency Analysis
One thousand four hundreds and forty-five Malays registered with the Malaysian Marrow Donor Registry were typed for HLA-A, HLA-B and HLA-DR. Fifteen HLA-A, twenty nine HLA-B and fourteen HLA-DR alleles were detected. The most common HLA-A alleles and their frequencies were HLA-A24 (0.35), HLA-A11 (0.21) and HLA-A2 (0.15). The most common HLA-B alleles were HLA-B15 (0.26), HLA-B35 (0.11) and HLA-B18 (0.10) while the most common HLA-DR alleles were HLA-DR15 (0.28), HLA-DR12 (0.27) and HLA-DR7 (0.10). A24-B15-DR12 (0.047), A24-B15-DR15 (0.03) and the A24-B35-DR12 (0.03) were the most frequent haplotypes. This data may be useful in determining the probability of finding a matched donor and for estimating the incidence of HLA associated diseases.
6