The guinea‐pig tracheal potential difference as an <i>in vivo</i> model for the study of epithelial sodium channel function in the airways

Abstract

The pharmacological sensitivity of the TPD to amiloride analogues and also to serine protease inhibitors are both consistent with that of ENaC activity in the guinea-pig trachea. The guinea-pig TPD therefore represents a suitable in vivo model of human airway epithelial ion transport.