Concepedia

Intravitreal toxicology and duration of efficacy of a novel antiviral lipid prodrug of ganciclovir in liposome formulation.

Lingyun Cheng, Karl Y. Hostetler, Sunan Chaidhawangul, Michael F. Gardner, James R. Beadle, Kelly Keefe, G Bergeron-Lynn, Gregory Severson, Kelly Soules, Andreas Mueller,

PubMed · 2000 · 49 citations · 20 references

Abstract

In the rabbit model of HSV-1 retinitis HDP-P-GCV acts as a long-lasting intravitreal injectable anti-CMV or anti-HSV compound. This self-assembling liposome system could be applicable for many compounds available for intraocular diseases.

References

20

Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus Infection

Frank J. Palella, Kathleen M. Delaney, Anne C. Moorman et al. · New England Journal of Medicine · 1998 · 9.5K citations

Standardizatlon of Vitreal inflammatory Activity in Intermediate and Posterior Uveitis

Robert B. Nussenblatt, Alan G. Palestine, Chi‐Chao Chan et al. · Ophthalmology · 1985 · 668 citations

, , +5

Treatment of Cytomegalovirus Retinitis with a Sustained-Release Ganciclovir Implant

David C. Musch, Daniel Martín, Judy F. Gordon et al. · New England Journal of Medicine · 1997 · 285 citations · Full text

Efficacy and Tolerance of Intravitreal Ganciclovir in Cytomegalovirus Retinitis in Acquired Immune Deficiency Syndrome

I Cochereau-Massin, Phuc LeHoang, M Lautier-Frau et al. · Ophthalmology · 1991 · 170 citations

, , +8

Long-term Intravitreal Ganciclovir Therapy for Cytomegalovirus Retinopathy

M. Heinemann · Archives of Ophthalmology · 1989 · 149 citations

, , +9