PubMed · 1991 · 22 citations · 0 references
Life SciencesBiochemistryMedicinal ChemistryBiochemical PharmacologyDrug DiscoveryEnzymologyBioinorganic ChemistryEnzyme InhibitionBioactive ConstituentsTraditional Chinese Medicine
According to IR, UV, MS and NMR spectra of the compounds isolated from the fresh stem of Dendrobium loddigesii Rolfe (a Chinese medicine), 3 constituents were identified. They are shihunidine, shihunine and dendrophenol (4,4'- dihydroxy-3,3',5-trimethoxybibenzyl). Chemical reactions showed that shihunidine was derived from shihunine during isolation. Shihunidine and shihunine were shown to be inhibitors of Na+, K+-ATPase of the rat kidney.