O-GlcNAc cycling enzymes control vascular development of the placenta by modulating the levels of HIF-1α

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

Life Sciences, Cell Biology, Molecular Biology +17

Cellular and developmental control of O₂ homeostasis by hypoxia-inducible factor 1α

Narayan V. Iyer, Lori E. Kotch, Faton Agani et al. · Genes & Development · 1998 · 2.5K citations · Full text

Life Sciences, Developmental Biology, Molecular Biology +16

Dynamic O-GlcNAc Modification of Nucleocytoplasmic Proteins in Response to Stress

Natasha E. Zachara, Niall O'Donnell, Win D. Cheung et al. · Journal of Biological Chemistry · 2004 · 570 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

O-GlcNAcylation Regulates Cancer Metabolism and Survival Stress Signaling via Regulation of the HIF-1 Pathway

Christina M. Ferrer, Thomas P. Lynch, Valerie L. Sodi et al. · Molecular Cell · 2014 · 435 citations · Full text

Life Sciences, Molecular Biology, Oncology +16

Direct protein–protein interaction between the intracellular domain of TRA-2 and the transcription factor TRA-1A modulates feminizing activity in <i>C. elegans</i>

David H. Lum, Patricia E. Kuwabara, David Zarkower et al. · Genes & Development · 2000 · 399 citations · Full text

Life Sciences, Genetics, Molecular Genetics +12