The effects of cardamonin on lipopolysaccharide‐induced inflammatory protein production and MAP kinase and NF<i>κ</i>B signalling pathways in monocytes/macrophages

Abstract

These results show that the inhibitory effect of cardamonin on LPS-induced iNOS induction is not mediated via effects on the initial activation of the NFkappaB or MAP kinase pathways but is due to a direct effect on transcription factor binding to DNA. However, although some selectivity in cardamonin's action is implicated by its inability to affect COX-2 expression, its exact mechanism(s) of action has yet to be identified.