Journal of Bacteriology · 1969 · 40 citations · 14 references
Life SciencesEndocrinologyPhysiologyImmunopharmacologyImmunophysiologyMetabolismDiabetes MellitusEndocrine BiochemistryGlucose HomeostasisInsulin Signaling In MetabolismRodent EndocrinologyEndocrine Causes Of HypoglycemiaEndotoxin ToxicityEndotoxin-mediated DiseaseInsulin ActionInsulin-like PeptidesInsulin-like SignalingInsulin-mediated HypoglycemiaMetabolic Causes Of Hypoglycemia
The mechanism of the hypoglycemic activity of endotoxin in hyperreactive BCG mice was investigated. The mechanism was found to be an inhibition of the synthesis of glucose from noncarbohydrate sources. The possibilities of an induced hypermetabolic state and an induced release of insulin in response to endotoxin as causes for the hypoglycemic response were essentially ruled out. In addition, no clear-cut evidence of an insulin-like action by endotoxin was found in the in vivo setting.
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