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Titration and Typing of Serum Antibodies in Tric Infections by Immunofluorescence
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1972
Year
ImmunohematologyTric InfectionsImmunocytochemical TechniqueImmunodeficienciesImmunologySerum AntibodiesImmunotherapyClinical EpidemiologySerologic TestingImmunochemistryAllergic RhinoconjunctivitisTric AntigenPrimary ImmunodeficiencyAllergyAutoimmune DiseaseAutoimmunityImmunologic DiseaseTunisian Children 67Antibody ScreeningIndirect Immunofluorescence TestPathogenesisMedicine
Abstract An indirect immunofluorescence test was employed to detect and quantitate serum antibodies to trachoma-inclusion conjunctivitis (TRIC) antigens of 6 types. This test was markedly more specific and sensitive than the group-reactive complement-fixation test. Striking differences in antibody patterns were detected in different groups of patients suffering from acute or chronic TRIC infections. Among Tunisian children 67% had antibody which was primarily directed against TRIC types A or C. Among American Indian students, 33% had antibody which was directed mainly against TRIC types B, D, or E, but not against A or C. Most San Francisco patients with acute oculogenital TRIC infection had antibodies broadly reactive with all 6 TRIC antigen types A to E. Some immunologic and epidemiologic implications of these results are discussed.