Studies on safety of Ganoderma lucidum

Abstract

To examine safety of Ganoderma lucidum, it was extracted with hot water (Fraction A). After the extract was dialyzed and freeze-dried, a polysaccharide fraction (Fraction B) was obtained and examined for acute and subacute toxicity. In the acute toxicity tests of Fr. A and Fr. B on mice, both agents did not show any serious and lethal effects. The results showed that 50% lethal doses were higher than 5,000 mg/kg. The experiments of oral administration of Fr. A (5,000 mg/kg) to mice for 30 days showed that there were no changes in body weight, hematological features and organ weight.