Pulmonary Function and Bronchial Hyperreactivity in Long-term Survivors of Bronchopulmonary Dysplasia

TLDR

The study examined nine bronchopulmonary dysplasia survivors at a mean age of 8.4 years. Most children exhibited persistent respiratory symptoms, airway obstruction, abnormal blood gases, and abnormal chest radiographs, with six of eight showing methacholine‑positive bronchial hyperreactivity that likely underlies early wheezing, and bronchodilator inhalation improved expiratory flow.

Abstract

Nine children with bronchopulmonary dysplasia were studied at a mean age of 8.4 years. Persistent respiratory symptoms were common. Pulmonary function tests demonstrated airway obstruction and abnormal blood gas levels in most. In six of eight children results of methacholine challenge tests were positive, indicating bronchial hyperreactivity. Abnormal chest radiographs persisted in eight children. The bronchial hyperreactivity is a likely consequence of airway damage in infancy and is the probable reason for episodic wheezing in the early years of life. Improvement in expiratory flow rates following bronchodilator inhalation suggests that such therapy may improve function in these children.