Transplacental transfer of paclitaxel, docetaxel, carboplatin, and trastuzumab in a baboon model.

Abstract

Variable plasma and/or tissue concentrations of taxanes, carboplatin, and trastuzumab were encountered in the fetal compartment. These data are important when cancer treatment is considered during pregnancy and underline the need for long-term follow-up of children after prenatal exposure to these cytotoxic agents.