ACTION OF BACTERIAL POLYSACCHARIDE ON TUMORS. III. REPEATED RESPONSE OF SARCOMA 37, IN TOLERANT MICE, TO SERRATIA MARCESCENS ENDOTOXIN.

Abstract

In the treatment of mice with Serratia marcescens polysaccharide, the pronounced tolerance induced by a single dose was surmounted when the subsequent doses were sufficiently increased. The overcoming of tolerance was observed in three phenomena: mortality of tumor-bearing mice; tumor-damaging potency of blood serum from treated mice; and repeated depression of tumor growth.