Study of the relationship between psoriasis and the polymorphic site C677T of methylenetetrahydrofolate reductase.

Abstract

OBJECTIVE: In order to investigate 5,10-methylenetetrahydrofolate reductase (MTHFR)'s polymorphic changes in psoriasis vulgaris. METHODS: We detected mutation of site C677V of MTHFR in 39 psoriastics by PCR-RFLP. RESULTS: Genotype frequencies of the psoriastics were C/C=20.15%, C/T=48.72% and T/T=30.77%; the allelic frequencies were C=0.4487 and T=0.5513. Homozygous mutant (TT) of the psoriastics was significantly different from the normal control group by X2 test. CONCLUSION: C677V mutant of MTHFR might be related with psoriasis.