Concepedia

Establishment of primary patient-derived xenografts of palliative TURP specimens to study castrate-resistant prostate cancer

Mitchell G. Lawrence, David Pook, Hong Wang, Laura H. Porter, Mark Frydenberg, John Kourambas, Sree Appu, Christine Poole, Emma K. Beardsley, Andrew Ryan,

The Prostate · 2015 · 40 citations · 17 references

DOI

Abstract

Primary PDXs of CRPC can be established from TURP specimens with modest success. The take rate can be increased if the original tissues contain sufficient numbers of actively proliferating cancer cells. Selecting specimens with abundant viable cancer will maximize the rate of engraftment and increase the efficiency of establishing PDXs that can be serially transplanted.

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Akash Kumar, Thomas A. White, Alexandra P MacKenzie et al. · Proceedings of the National Academy of Sciences · 2011 · 266 citations · Full text