Concepedia

Characterization of MENX‐associated pituitary tumours

Ilaria Marinoni, M. Lee, Steffeni Mountford, Aurel Perren, Ilaria Bravi, Luise Jennen, Annette Feuchtinger, Jacques Drouin, Federico Roncaroli, Natalia S. Pellegata

Neuropathology and Applied Neurobiology · 2012 · 18 citations · 38 references

DOI

Abstract

Our results suggest that p27 function is critical to regulate gonadotroph cells growth. The MENX syndrome represents a unique model to elucidate the physiological and molecular mechanisms mediating the pathogenesis of gonadotroph adenomas.

References

38

Effects of an Rb mutation in the mouse

Tyler Jacks, Amin Fazeli, Earlene M. Schmitt et al. · Nature · 1992 · 1.8K citations

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Mice Lacking p27 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors

Keiko Nakayama · Cell · 1996 · 1.6K citations · Full text

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A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27 -Deficient Mice

Matthew L. Fero, Michael J. Rivkin, Michael Tasch et al. · Cell · 1996 · 1.5K citations · Full text

Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27

Hiroaki Kiyokawa, Rhonda D. Kineman, Katia Manova‐Todorova et al. · Cell · 1996 · 1.3K citations · Full text

Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors.

Donna M. Simmons, J W Voss, Holly A. Ingraham et al. · Genes & Development · 1990 · 638 citations · Full text

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