Recent Advances in Granulation Techniques

Abstract

Granulation is one of the most important unit operation in the production of pharmaceutical oral dosage forms. Granulation is used mainly to improve flow, compressibility of powders, and to prevent segregation of the blend components, improve content uniformity, and eliminate excessive amounts of fine particles. The results will be improved yields, reduced tablet defects, increased productivity, and reduced down time. Particle size of the granules is mainly affected by the quantity and feeding rate of granulating liquid. Pharmaceutical granules typically have a size range between 0.2 and 4.0 mm, depending on their subsequent use. Among all granulating techniques, Moisture Activated Dry Granulation (MADG) technology is widely used in granulation of moisture sensitive active pharmaceutical ingredients. The objective of present work is to focus on the novel granulation technologies.