The<scp>TRPA</scp>1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives

Abstract

Evidence that in rodents the nociceptive/hyperalgesic effect produced by TRPA1 activation is blocked by PDs suggests that a similar pathway is attenuated by PDs in humans and that TRPA1 antagonists could be novel analgesics, devoid of the adverse haematological effects of PDs.