Studies on the distribution and co valent binding of 1,1-dichloroethylene in the mouse

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

Alan Poland, Edward Glover, Andrew S. Kende · Journal of Biological Chemistry · 1976 · 1.4K citations · Full text

Pharmacy, Pharmacology, Toxicology +17

Mutagenicity in vitro and potential carcinogenicity of chlorinated ethylenes as a function of metabolic oxirane formation

Helmut Greim, Gerhard Bonse, Z. Radwan et al. · Biochemical Pharmacology · 1975 · 233 citations

Pharmacy, Environmental Sciences, Toxicology +16

Mutagenic and alkylating metabolites of halo-ethylenes, chlorobutadienes and dichlorobutenes produced by rodent or human liver tissues

Helmut Bartsch, C. Malaveille, Alain Barbin et al. · Archives of Toxicology · 1979 · 222 citations

Veterinary Medicine, Environmental Sciences, Toxicology +12

Effect of 18 HR fast and glutathione depletion on 1,1-dichloroethylene-induced hepatotoxicity and lethality in rats

Rudolph J. Jaeger, Rory B. Conolly, Sheldon D. Murphy · Experimental and Molecular Pathology · 1974 · 139 citations

Veterinary Medicine, Pharmacology, Toxicology +14

Differential induction of cytosolic eposide hydrolase, microsomal epoxide hydrolase, and glutathione S-transferase activities

Bruce D. Hammock, Kenji Ota · Toxicology and Applied Pharmacology · 1983 · 135 citations

Life Sciences, Biochemistry, Molecular Biology +16