PM01183, a new DNA minor groove covalent binder with potent <i>in vitro</i> and <i>in vivo</i> anti‐tumour activity

Abstract

PM01183 is shown to bind to selected DNA sequences and promoted apoptosis by inducing double-strand breaks at nanomolar concentrations. The potent anti-tumour activity of PM01183 in several murine models of human cancer supports its development as a novel anti-neoplastic agent.