Onabotulinumtoxin <scp>A</scp> significantly attenuates bladder afferent nerve firing and inhibits <scp>ATP</scp> release from the urothelium

Abstract

These data indicate that OnaBotA attenuates the bladder afferent nerves involved in micturition and bladder sensation, suggesting that OnaBotA may exert its clinical effects on urinary urgency and the other symptoms of overactive bladder syndrome through its marked effect on afferent nerves.