PubMed · 1972 · 95 citations · 0 references
MedicineDermatologyToxicologyCarcinogenesisNeoplasiaRadiobiologyBiological Effects Of RadiationCholesterol MetabolismEnvironmental CarcinogenesisRadiation CarcinogenesisSkin Cancer Risk FactorsUltraviolet Radiation BiologyMechanisms Of CarcinogenicitySkin CarcinogenesisSolar Ultraviolet ExposureUltraviolet Light ExposureUltraviolet Radiation DamageUltraviolet Radiation-induced Carcinogenesis
Summary Cholesterol α-oxide (cholestan-5α,6α-epoxy-3β-ol), known to be carcinogenic, was formed in the skin of hairless mice in response to UV radiation. The levels of compound formed were dose dependent. Three criteria, namely, comparable effects by both the primary incitant (ultraviolet light) and cholesterol α-oxide, the same predisposing specificity, and a direct relationship between the ability of the primary incitant to form tumors and produce cholesterol α-oxide, are suggested as the minimum required to establish a causal involvement of this compound in the etiology of UV carcinogenesis.