Lipopolysaccharide enhanced renal vascular response to endothelin‐1 through <scp>ET_A</scp> overexpression in portal hypertensive rats

Abstract

LPS-induced systemic hypotension induces a paradoxical change of renal vascular response to endothelin-1 between SHAM and PVL rats. LPS-induced renal vascular hyperreactivity in PVL rats was associated with upregulation of renal ETA and subsequent activation of ERK1/2 signaling.