Arkadia-Smad7-Mediated Positive Regulation of TGF-β Signaling in a Rat Model of Tubulointerstitial Fibrosis

Abstract

Reduction of Smad7 resulting from ubiquitin-dependent degradation may be mainly attributed to Arkadia, and Arkadia-Smad7-mediated positive regulation of TGF-beta signaling may play a promoting role in the progression of tubulointerstitial fibrosis.